Antidepressants such as SSRIs can cause weight gain in some people and weight loss in others. We explain how that works:
1. Weight loss is often about their effect of SSRIs on increasing indifference which may then reduce emotional eating.
2. Weight gain is with SSRIs is often about their effects on increasing someone’s indifference in their food choices.

This clip explains how SSRI/SNRI affect sensitivity: https://www.youtube.com/watch?v=u_7LwL5EmAs

Other antidepressants like Tricyclic antidepressants and Mirtazapine can cause sedation because of their antihistamine effects on increasing appetite. Thats why some medications which cause drowsiness also cause increased appetite.

SSRIs include aropax/paroxetine, zoloft/sertraline, prozac/fluoxetine, luvox/fluvoxamine, lexapro/escitalopram and cipramil/citalopram. The mostly interact with the SERT protein to increase serotonin residence in the synapse. They minimally affect the Histamine receptor.

Tricyclic antidepressants (TCA) include endep/amitriptyline, anafranil/clomipromine, dothiepin, nortriptyline etc. Generally have significant effect on Serotonin and noradrenaline reuptake (SERT and NET) as well as hitting specific serotonin receptors (e.g. clomipramine avidly binds 5-HT2c and 5-HT6). They bind Alpha1 and potently bind H1.

Mirtazepine (Avanza) is a tetracyclic antidepressant, also called a “noradrenergic and specific serotonergic antidepressant”, but it’s not very specific. While it has negligible effect on serotonin or noradrenaline reuptake (negligible SERT or NET effect) but strongly interacts with a number of other receptors including serotonergic 5-HT2C, 5-HT3, Alpha2A, Alpha2C and H1.

more at www.thepsychcollecitve.com

#emotionaleating #SSRI #weightgain

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In this video Doctor O’Donovan explains key facts you need to know about a medication called METFORMIN used to treat type 2 diabetes (also known as Glucophage, Fortamet, Axpinet, Diagemet, Glucient, Metabet).

In the video we cover:

What is metformin? (0.36)
Who can and can’t take it? (1.34)
How to take it (2.36)
Side effects (4.49)
Use in pregnancy (7.40)
Interactions (8.15)

Key facts
– Not everyone gets diabetes symptoms, so taking metformin may not make you feel any different. That does not mean it is not working, so keep on taking it.

– It’s best to take metformin with a meal to reduce the side effects.
The most common side effects are feeling and being sick, diarrhoea, stomach ache and loss of appetite. Vitamin B12 deficiency is also a common side effect of taking metformin in higher doses or for long periods.

– Metformin does not cause weight gain, unlike some other diabetes medicines.

– If you have diabetes, you can get free prescriptions for all of your medicines, not just your diabetes ones. You’ll need to have a medical exemption certificate.

Further information via NHS website:

https://www.nhs.uk/medicines/metformin/

Patient information leaflet:

https://www.medicines.org.uk/emc/product/594/pil

#doctor #diabetes #medication #pharmacy
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The video is intended as an educational resource only. The information within this video or on this channel isn’t designed to replace professional input, so if you have any medical issues please consult a medical provider. No professional relationship is being created by watching this video. Dr. O’Donovan cannot give any individual medical advice. All information should be verified for accuracy by the individual user. Dr O’Donovan accepts no responsibility for individual interpretation of data, although it is always accurate to the best of his knowledge at the time of the video being published. This is an EDUCATIONAL video. Images are used in accordance with fair use guidelines.

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Nutritionist Maya Feller discusses what to know about the new findings that some people were able to put their Type 2 diabetes into remission using a rigorous liquid diet instead of medication.
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